Creating safer polio vaccine strains for the post-eradication era

(PLOS) While the goal of polio virus eradication is in sight, there are concerns about post-eradication manufacturing and stockpiling vaccine stores containing live virus that could escape and repopulate the environment. A study published on Dec. 31 in PLOS Pathogens reports the generation of new vaccine strains that appear both effective and unable to cause disease after accidental or intended release.